New Phenotypes of Potato Co-induced by Mismatch Repair Deficiency and Somatic Hybridization

Irinotecan and mismatch repair deficiency.

We read the recent publications of Ychou et al. [1, 2] on ‘adjuvant’ irinotecan-based chemotherapy in high-risk localized colorectal cancer (CRC) and after resection of liver-confined metastatic disease with great interest. In contrast to the improved outcome provided by oxaliplatin-based adjuvant treatment of early-stage disease, there is now a body of evidence showing that the addition of iri...

Somatic Hypermutation, Transcription, and DNA Mismatch Repair

hypermutation, suggesting that cis-acting sequences outside the mutable region regulate and target mutation. However, almost nothing is known about the detailed molecular mechanisms or transacting proteins that are responsible for V-region hypermutation. Because the mutational process begins just downstream of the promoter and requires transcriptional en-hancers (Neuberger et al., 1998), it has...

Constitutional mismatch repair-deficiency syndrome.

The mismatch repair (MMR) machinery contributes to genome integrity and the MLH1, MSH2, MSH6 and PMS2 genes play a crucial role in this process. MMR corrects single base-pair mismatches and small insertion-deletion loops that arise during replication. Moreover, the MMR system is involved in the cellular response to a variety of agents that damage DNA and in immunoglobulin class switch recombina...

Mismatch repair, somatic mutations, and the origins of cancer.

This paper outlines the basic properties of a newly recognized pathway that should enable somatic cells to generate double-stranded mutations in the complete absence of cell proliferation. Recognition of the existence of this pathway provides us with the basis for a better understanding of a number of important biological phenomena and, in particular, may help us to understand the origins of ca...

Recognizing Lynch syndrome by DNA mismatch repair deficiency